Pakistan Pharma

Dependal - Dependal-M


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Dependal is made available as tablets containing furazolidone 100mg and metronidazole 300mg and also as apricot-flavored suspension, each 5ml containing furazolidone 25mg and metronidazole 75mg (present metronidazole benzoate).

Clinical information

Dependal is a combination of furazolidone, a broad spectrum antibacterial and anti protozoal agent, which is effective against many species and strains of Escherichia coli, salmonella, shigella, proteus, streptococcus, staphylococcus, coliforms, enterococci and giardia lamblia, and metronidazole, which is effective in amoebiasis and giardiasis.


Dependal is recommended for the treatment of diarrhoea and dysentery of protozoal, bacterial or mixed origin amoebiasis (intestinal and extra intestinal disease,and that of symptomless cyst passers); bacillary dysentery, giardiasis and food poisoning caused by the many susceptible strains and species of gram-positive and gram-negative bacteria.

Dosage and administration


Dependal Tablet: 1 tablet 3 times daily,

Dependal Suspension: 4 x 5 ml 3 times daily

Children above 5 years

Dependal Tablet: ½ tablet 3 times daily

Dependal Suspension: 2 x 5 ml 3 times daily

1 – 5 years

Dependal Tablet: 1/4 tablet 3 times daily,

Dependal Suspension: 1 x 5 ml 3 times daily

Priority should be given to oral parental rehydration therapy in patients where dehydration as occurred or is suspected.

Most patients treated for diarrhoea respond to Dependal within 1 – 2 days. However, to ensure adequate control of infections, treatment should be continued for 2 – 5 days amoebiasis would require 5 – 10 days treatment.

Contra-indications, warnings

Dependal should not be given to infants one year of age and in patients with active disease of CNS, severe liver damage with evidence of history of blood dyscrasias or those sensitive to furazolidone or metronidazole.


Furazolidone inhibits some enzymes including monoamine oxidase. It is less potent phenelzine but may enhance the effects of indirect-acting sympathomimetics and anti-depressants foods with a high tyramine content and alcohol should be avoided.

Acute hemolytic anemia may occur in patients with a genetic deficiency of glucose-6-phosphate dehydrogenate. Agranulocytosis has been repoted.

Metronidazole has been reported to cause potentiation of oral anti-coagulant therapy, prothrombin times should be monitored during co-administration.

Use in pregnancy and lactation

Metronidazole crosses the placental barrier and enters the foetal circulation rapidly. When administered to nursing mothers, it is secreted in breast milk. Although metronidazole has not been shown to be teratogenic in either animal or human studies, data is not adequate to rule out a possible teratogenic effect. Therefore Dependal should not be used in the first trimester of pregnancy.

Adverse reaction

Nausea, vomiting, headache, gastro-intestinal discomfort, unpleasant taste and a mild rash may occur and may be minimized or eliminated by reduction in dosage.

Darkening of urine due to metabolites of furazolidone has been reported.









 Pakistan Pharma